Do NOT use Zelnorm if:

• you are allergic to any ingredient in Zelnorm
• you have moderate to severe liver problems or severe kidney problems
• you have a history of certain bile duct or gallbladder problems, blockage of the bowel, or abdominal adhesions
• you have diarrhea or you have diarrhea often.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Zelnorm. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of certain severe bowel problems (eg, ischemic colitis) or gallbladder, liver, or kidney problems
• if you have low blood pressure or are dehydrated.

Some medicines may interact with Zelnorm. However, no specific interactions with Zelnorm are known at this time. Ask your health care provider if Zelnorm may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

• Zelnorm may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Zelnorm with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Use Zelnorm with caution in the elderly; they may be more sensitive to its effects, especially diarrhea.
• Zelnorm should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.
• Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zelnorm while you are pregnant. It is not known if Zelnorm is found in the breast milk. Do not breast-feed while taking Zelnorm.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; headache.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; diarrhea with severe cramping; fainting; new or worsening stomach pain; rectal bleeding; severe or persistent diarrhea or dizziness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.